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Vyvanse Addiction: Signs and Treatment Options

Vyvanse (lisdexamfetamine dimesylate) is a prescription stimulant used to treat ADHD (attention deficit hyperactivity disorder) and moderate to severe binge eating disorder.

While it is designed as a pro-drug to reduce the potential for abuse, Vyvanse may still be addictive, leading to substance use disorder if misused. This guide explains the effects of Vyvanse, signs of Vyvanse addiction, and available treatment options.

Is Vyvanse addictive?

Vyvanse is classified as a Schedule II stimulant, meaning it has a recognized medical use but a potential for addiction. While it has a lower potential for abuse than some other stimulants, using Vyvanse outside of medical guidelines can lead to dependence and serious health risks.

Addiction to Vyvanse develops when a person starts craving the drug and feels unable to function without it. This can lead to compulsive Vyvanse use, difficulty stopping, and experiencing withdrawal symptoms.

How does Vyvanse lead to addiction?

Vyvanse affects the central nervous system, and long-term stimulant use disorder can develop when misuse occurs. Addiction risk increases when you:

  • Take it in higher doses than prescribed: Increased dopamine release creates a euphoric effect that can reinforce drug-seeking behavior.
  • Use Vyvanse without a medical need: Taking the drug without a diagnosis of ADHD or binge eating disorder increases the risk of Vyvanse abuse.
  • Snort or crush Vyvanse: Altering the way Vyvanse is taken speeds up absorption, intensifying its effects and increasing the potential for addiction.
  • Use Vyvanse for cognitive enhancement: Misuse for focus, staying awake, or productivity can lead to dependence.

Signs and symptoms of Vyvanse addiction

Behavioral signs 

People who are addicted to Vyvanse may show noticeable changes in their actions. These behaviors may indicate a substance use disorder:

  • Obsessing over Vyvanse: Constantly thinking about when to take Vyvanse or worrying about running out.
  • Taking more than prescribed: Increasing doses to maintain the same effects.
  • Ignoring negative consequences: Continuing Vyvanse use despite health problems, poor work performance, or relationship issues.
  • Seeking multiple sources: Going to different doctors, lying about symptoms, or obtaining Vyvanse illegally.
  • Engaging in risky behaviors: Driving under the influence or mixing Vyvanse with other substances.

Physical signs 

Vyvanse affects the central nervous system, causing physical symptoms. These signs may indicate an addiction:

  • Trouble sleeping: Difficulty falling or staying asleep due to overstimulation.
  • Unexplained weight loss: Appetite suppression leading to malnutrition.
  • Increased heart rate and blood pressure: Risk of cardiovascular issues.
  • Frequent headaches or dizziness: Persistent discomfort or lightheadedness.
  • Muscle tension and jaw clenching: Physical tension and involuntary movements.

Psychological signs 

Vyvanse misuse can impact mental health. Symptoms of Vyvanse addiction include:

  • Severe anxiety and paranoia: Constant nervousness or fear of being watched.
  • Extreme mood swings: Sudden anger, irritability, or depression.
  • Feeling exhausted when not using Vyvanse: Energy crashes when the drug wears off.
  • Difficulty concentrating without Vyvanse: Feeling incapable of functioning without it.
  • Hallucinations or delusions: In rare cases, high doses can cause psychotic symptoms.

Vyvanse withdrawal symptoms

When someone stops using Vyvanse after prolonged misuse, they may experience withdrawal symptoms as the body adjusts. Common Vyvanse withdrawal symptoms include:

  • Extreme fatigue: Persistent tiredness and low energy.
  • Depression: Intense sadness due to dopamine imbalance.
  • Irritability and mood swings: Frustration and sudden emotional shifts.
  • Difficulty concentrating: Struggling with memory and focus.
  • Increased appetite: Intense hunger and possible weight gain.
  • Sleep disturbances: Insomnia or excessive sleep.
  • Cravings for Vyvanse: Strong urges to take more.
  • Anxiety and restlessness: Nervousness and agitation.

Side effects of Vyvanse misuse

Vyvanse misuse over an extended period can harm multiple organs and bodily systems. While primarily affecting the central nervous system, prolonged use can cause lasting damage to the heart, liver, kidneys, and mental health. The severity of these effects depends on the dosage, frequency of use, and individual health factors.

Cardiovascular effects

Vyvanse is a stimulant, meaning it increases heart rate and blood pressure. Over time, chronic use can lead to:

  • High blood pressure (hypertension): Persistent elevated blood pressure increases the risk of heart disease and stroke.
  • Irregular heartbeat (arrhythmia): Disruptions in normal heart rhythms can be dangerous and sometimes life-threatening.
  • Enlarged heart (cardiomyopathy): The heart muscle may thicken, reducing its ability to pump blood efficiently.
  • Increased risk of heart attack: Prolonged stimulant use places extra strain on the cardiovascular system, potentially leading to serious complications.

Neurological and mental health effects

Since Vyvanse acts on the central nervous system, long-term use can significantly affect brain function and mental well-being. Common effects include:

  • Psychosis: In severe cases, high doses can lead to hallucinations, delusions, and detachment from reality.
  • Cognitive decline: Memory problems, reduced concentration, and difficulty processing information.
  • Emotional instability: Mood swings, heightened irritability, and frequent emotional outbursts.
  • Anxiety and paranoia: Long-term stimulant use may cause excessive worry, nervousness, and suspicion.
  • Depression: Changes in dopamine levels can lead to feelings of sadness, hopelessness, and decreased motivation.

Impact on liver health

Vyvanse is metabolized in the liver, and excessive use may result in liver strain and dysfunction. Risks include:

  • Elevated liver enzymes: Indicating inflammation or damage, which can progress to liver disease.
  • Hepatotoxicity: In rare cases, prolonged Vyvanse misuse may contribute to liver toxicity.
  • Increased sensitivity to other medications: Impaired liver function may affect how the body processes additional drugs.

Effects on kidney function

The kidneys play a key role in filtering Vyvanse from the bloodstream, and long-term use can contribute to:

  • Dehydration: Stimulants suppress thirst, which can lead to kidney strain and an increased risk of kidney stones.
  • Reduced kidney function: Chronic high blood pressure caused by stimulant use can damage kidney structures over time.
  • Electrolyte imbalances: Disruptions in sodium and potassium levels may occur due to excessive fluid loss.

Gastrointestinal issues

Vyvanse can interfere with normal digestion and metabolism, leading to:

  • Chronic nausea and vomiting: Irritation of the digestive tract, especially at high doses.
  • Loss of appetite and malnutrition: Suppressed hunger may result in weight loss and deficiencies in essential nutrients.
  • Constipation or diarrhea: Disruptions in gut motility can lead to inconsistent bowel movements.

Online Therapy for ADHD and Vyvanse addiction

Long-term Vyvanse misuse can take a serious toll on your health, making early support essential. At Modern Recovery, we provide online intensive outpatient program (IOP) for those facing Vyvanse dependence and ADHD challenges.

ADHD & addiction care

  • Tailored support for managing ADHD and breaking free from Vyvanse.

Flexible & convenient

  • Get professional treatment from home without disrupting your routine.

Peer support

  • Connect with others on the same journey for encouragement and support.

ADHD & addiction care

  • Tailored support for managing ADHD and breaking free from Vyvanse.

Flexible & convenient

  • Get professional treatment from home without disrupting your routine.

Peer support

  • Connect with others on the same journey for encouragement and support.

Online therapy covered by insurance does exist. Modern Recovery works with leading insurance providers across the United States to bring you quality mental health treatment that’s both accessible and affordable.

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Vyvanse addiction treatment

Overcoming Vyvanse addiction requires a combination of medical care, therapy, and lifestyle changes. A well-structured treatment program can help individuals manage withdrawal symptoms, address underlying mental health conditions, and develop healthier coping strategies.

Medical treatment

Vyvanse addiction treatment often starts with inpatient treatment or outpatient programs at treatment centers. These treatments provide medical supervision and support to ensure a safe recovery. Treatment options include:

  • Medically supervised detox: This process helps individuals gradually lower their Vyvanse intake under medical supervision. 
  • Medication support: In some cases, doctors may prescribe medications to help manage anxiety, depression, or other mental health issues linked to Vyvanse dependence. 
  • Monitoring for co-occurring disorders: Many individuals with Vyvanse addiction also struggle with conditions like ADHD or depression. Proper treatment ensures these conditions are managed alongside addiction recovery, reducing the risk of relapse.

Behavioral therapy and support

Therapy is essential for overcoming Vyvanse dependence and learning healthier coping strategies. Common therapy options include:

  • Cognitive-behavioral therapy (CBT): This therapy helps individuals identify thoughts and behaviors that contribute to substance use. It also teaches coping skills to manage stress and avoid triggers that could lead to relapse.
  • Motivational interviewing (MI): This method encourages individuals to explore their motivations for quitting Vyvanse. It helps strengthen commitment to long-term recovery by focusing on personal goals and values.
  • Group therapy: Connecting with others in recovery provides emotional support and accountability. Sharing experiences and challenges with a supportive community can make the journey to sobriety less isolating.

Lifestyle changes for recovery

Sustaining recovery from Vyvanse addiction requires long-term lifestyle adjustments. Healthy habits can support physical and mental well-being, reducing the risk of relapse. Recommended changes include:

  • Structured routine: Establishing a daily schedule that includes regular sleep, meals, and activities helps maintain stability and reduces the likelihood of relapse.
  • Stress management: Learning to manage stress through relaxation techniques like meditation, deep breathing, and yoga can help prevent the urge to use Vyvanse as a coping mechanism.
  • Physical health focus: Prioritizing a balanced diet, staying hydrated, and engaging in regular physical activity supports overall well-being and helps restore natural energy levels.

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Sources

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3. Siffel C, Page M, Maxwell T, Thun B, Kolb N, Rosenlund M, von Bredow D, Keja J. Patterns of lisdexamfetamine dimesylate use in children, adolescents, and adults with attention-deficit/hyperactivity disorder in Europe. J Child Adolesc Psychopharmacol. 2020 Sep;30(7):439-47. doi:10.1089/cap.2019.0173.

4. Ezard N, Clifford B, Dunlop A, Lintzeris N, et al. Safety and tolerability of oral lisdexamfetamine in adults with methamphetamine dependence: a phase-2 dose-escalation study. BMJ Open. 2020 May;11(5):e044696. doi: 10.1136/bmjopen-2020-044696.

5. Sakai C. Pharmacological properties and clinical effects of the ADHD drug, lisdexamfetamine (Vyvanse® capsules 20 mg and 30 mg) [Article in Japanese]. Nihon Yakurigaku Zasshi. 2020;155(6):413-25. doi:10.1254/fpj.20033.